The new phenoxy herbicide formulations, including Enlist Duo™ (Dow), XtendiMax® (Monsanto), Engenia™ (BASF), and FeXapan™ (DuPont), offer growers new management options along with new application requirements. To alleviate problems related to applying new phenoxy herbicide formulations in soybeans as well as to increase herbicide performance, manufacturers have established application requirements. Here we discuss some of the key application factors to consider.